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目的:探讨转移相关基因1的表达与膀胱移行细胞癌的发生及复发的关系。方法:收集临床膀胱移行细胞癌患者120例,其中初发病例62例,复发病例58例,采用RT-PCR检测MTA-1 mRNA表达的变化,Western blot检测MTA-1蛋白表达的变化。结果:与对照组比较,初发组病例和复发组病例膀胱癌组织的MTA-1 mRNA和蛋白质的表达水平均明显上调,且复发组上调更为显著。结论:转移相关基因1的表达与膀胱癌的发生呈正相关,且转移相关基因1表达的上调可能导致膀胱移行细胞癌的复发。
Objective: To investigate the relationship between the expression of metastasis associated gene 1 and the occurrence and recurrence of bladder transitional cell carcinoma. Methods: Totally 120 patients with clinical bladder transitional cell carcinoma were collected. Among them, 62 cases were newly diagnosed and 58 cases were recurrent. The expression of MTA-1 mRNA was detected by RT-PCR and the expression of MTA-1 was detected by Western blot. Results: Compared with the control group, the expression levels of MTA-1 mRNA and protein in the primary tumor group and the recurrent group were significantly increased, and the up-regulation was more significant in the recurrence group. CONCLUSION: The expression of metastasis-associated gene 1 is positively correlated with the occurrence of bladder cancer, and the up-regulation of metastasis-associated gene 1 may lead to the recurrence of bladder transitional cell carcinoma.