论文部分内容阅读
本文测定了 ＮＩＤＤＭ合并视网膜病变患者２１例、无视网胰病变患 者１９例及正常对照２０例的红细胞聚集性有关参数。的果显示，ＮＩＤＤＭ视网膜病 变组的低切全血粘度、红细胞聚集指数均显著高于无视网膜病变组及对照组（Ｐ＜ ０．０１）。ＮＩＤＤＭ组和合并视网膜病变组的血沉及血沉方程Ｋ值均显著高于对照组 （Ｐ＜０．０１）。ＮＩＤＤＭ视网膜病变组的血浆纤维蛋白原水平及糖化血清蛋白指数 均显著高于无视网膜病变组和对照组（Ｐ＜０．０５，Ｐ＜０．０１）。ＮＩＤＤＭ视网膜病变 组血清白蛋白及超氧化物歧化酶（ＳＯＤ）均显著低于无视网膜病变组和对照组（Ｐ ＜０．０５，Ｐ＜０．０１）．ＮＩＤＤＭ视网膜病变组红细胞聚集指数与血浆纤维蛋白原、 糖化血清蛋白指数呈显著正相关（ｒ值 ０．４５２、０．４４６，Ｐ＜０．０５）．与血清ＳＯＤ、白蛋 白呈显著负相关（ｒ－０．４６２、－０．４３９，Ｐ＜０．０５）．结果提示，ＮＩＤＤＭ合并视网膜 病变患者上细胞聚集性增高，这种增高与血中纤维蛋白原水平增高，蛋白质非酶糖 基化增加、ＳＯＤ及白蛋白水平降低有关．
In this paper, 21 patients with NIDDM complicated with retinopathy, 19 patients without retinopathy and 20 normal controls were enrolled in this study. The results showed that the low cut-whole blood viscosity and erythrocyte aggregation index in NIDDM group were significantly higher than those in non-retinopathy group and control group (P <0.01). Erythrocyte sedimentation rate and erythrocyte sedimentation rate K values of NIDDM group and combined retinopathy group were significantly higher than those of control group (P <0.01). Plasma fibrinogen levels and glycated serum protein index were significantly higher in patients with NIDDM than those without retinopathy and controls (P <0.05, P <0.01). Serum albumin and superoxide dismutase (SOD) in NIDDM retinopathy group were significantly lower than those in non-retinopathy group and control group (P <0.05, P <0.01). There was a significant positive correlation between erythrocyte aggregation index and plasma fibrinogen and glycosylated serum protein index in NIDDM retinopathy group (r = 0.452, 0.446, P <0.05). And serum SOD, albumin was significantly negatively correlated (r-0.462, -0.439, P <0.05). The results suggest that patients with NIDDM complicated with retinopathy increased cellular aggregation, such an increase in blood and fibrinogen levels, increased protein non-enzymatic glycation, SOD and albumin levels decreased.