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目的本研究通过对352名参与者进行5年的随访,探讨成纤维细胞生长因子(FGF-21)与代谢综合征(MS)发生发展的关系。方法记录参与者一般临床资料,采用酶联免疫吸附法(ELISA)测定基线及随访5年后参与者血清FGF-21浓度水平,对比分析MS组与非MS组间FGF21浓度水平的差异,并采用多因素Logistic回归分析FGF21是否为MS的独立危险因素。结果 MS组参与者基线FGF21浓度水平明显高于非MS组,差异有统计学意义(P<0.05);MS组参与者随访5年后FGF21浓度水平明显高于基线FGF21浓度水平,差异有统计学意义(P<0.05),非MS组参与者随访5年后血清FGF21浓度水平与基线FGF21浓度水平差异无统计学意义(P>0.05);多因素Logistic回归分析发现,腰围、BMI、TG、HOMA-IR、FGF21是影响MS发生的独立危险因素。结论血清FGF-21浓度水平高是MS发生的独立危险因素,未来有可能成为干预MS有效的分子靶点。
Objective To investigate the relationship between fibroblast growth factor (FGF-21) and the development of metabolic syndrome (MS) by observing 352 participants for 5 years. Methods The clinical data of participants were recorded. The concentration of serum FGF-21 in the baseline and 5-year follow-up were measured by enzyme-linked immunosorbent assay (ELISA). The difference of FGF21 levels between MS group and non-MS group was analyzed and compared Multivariate Logistic regression analysis of whether FGF21 was an independent risk factor for MS. Results At baseline, FGF21 levels in MS group were significantly higher than those in non-MS group (P <0.05). FGF21 levels in MS group were significantly higher than those in baseline group after 5 years of follow-up (P <0.05). There was no significant difference in serum FGF21 levels between baseline and baseline levels after 5 years of follow-up in non-MS group (P> 0.05). Multivariate logistic regression analysis showed that waist circumference, BMI, TG, HOMA -IR, FGF21 is an independent risk factor affecting the occurrence of MS. Conclusion The high serum FGF-21 level is an independent risk factor for MS and may become an effective molecular target for intervention in the future.