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目的:研究大黄酸对大鼠非酒精性脂肪肝(NAFLD)的防治作用及其部分机制。方法:采用高脂饲料12周喂养建立大鼠NAFLD模型;50只SD大鼠随机分为5组:正常对照组、模型组、大黄酸低、中、高剂量[100,200,400 mg/(kg.d)]组(每组10只)。给药4周后处死大鼠,计算肝脏指数,观察肝组织病理形态学变化,全自动生化仪检测血清ALT、AST、FFA、LDL-C、HDL-C、TG和TC含量;比色法测定肝组织MDA、GSH-PX水平;Real-time PCR检测肝脏组织PPAR-γmRNA表达。结果:与模型组比较,大黄酸给药可使大鼠肝组织脂肪变性明显减轻,肝脏指数明显降低;各给药组血清ALT、AST、FFA、TG、TC和肝脏MDA水平降低,肝脏GSH-PX活力升高(P<0.05或0.01);模型组肝脏PPAR-γmRNA表达明显升高(P<0.01),大黄酸干预组则明显降低其表达(P<0.01)。结论:大黄酸对大鼠NAFLD具有较好的防治作用,其机制可能与清除氧自由基、减少脂质过氧化产物和改善脂质代谢紊乱有关。
Objective: To study the preventive and therapeutic effects of rhein on non-alcoholic fatty liver disease (NAFLD) in rats and its partial mechanisms. Methods: NAFLD rats were fed with high-fat diet for 12 weeks. 50 SD rats were randomly divided into 5 groups: normal control group, model group, low, middle and high doses of rhein (100,200,400 mg / (kg · d) ] Group (10 per group). Four weeks after the administration, the rats were sacrificed and the liver index was calculated. The pathological changes of the liver were observed. The levels of ALT, AST, FFA, LDL-C, HDL-C, TG and TC were detected by the automatic biochemical analyzer. Liver tissue MDA, GSH-PX levels; Real-time PCR detection of liver tissue PPAR-γmRNA expression. Results: Compared with the model group, rhein administration significantly reduced hepatic steatosis and decreased liver index. Serum levels of ALT, AST, FFA, TG, TC, and liver MDA decreased, PX increased (P <0.05 or 0.01). The expression of PPAR-γmRNA in the model group was significantly increased (P <0.01), and decreased significantly in the rhein intervention group (P <0.01). Conclusion: Rhein has a good preventive and therapeutic effect on NAFLD in rats. The mechanism may be related to scavenging oxygen free radicals, reducing lipid peroxidation products and improving lipid metabolism disorders.