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目的 :探讨 p5 3、nm2 3和EGF R蛋白表达与胃癌临床病理特征的关系。 方法 :运用免疫组织化学方法研究 5 7例胃癌、2 0例异型增生和 2 0例肠上皮化生和 10例正常胃粘膜 p5 3、nm2 3和EGF R蛋白的表达。 结果 :正常胃粘膜三种蛋白均阴性 ,肠上皮化生p5 3和nm2 3均未表达 ,而EGF R阳性率为 5 %。异型增生和胃癌组织中 p5 3阳性率分别为 15 %和 5 4 4% ;nm2 3阳性率分别为 5 %和 6 3 2 % ;EGF R阳性率分别为 45 %和 5 6 1%。p5 3与多项临床病理恶性特征均无密切关联 ;nm2 3表达与胃癌的瘤体大小、生长方式和预后关系密切 ;EGF R表达与胃癌的分化程度和预后呈负相关而与淋巴结转移呈正相关。结论 :同时检测EGF R、p5 3和nm2 3有助于胃癌早期诊断 ;胃癌组织中EGF R蛋白的表达可作为预测预后的一个指标 ,同时检测nm2 3可提高其可靠性 ,但nm2 3作为预测胃癌预后的独立指标以及 p5 3蛋白表达与胃癌临床病理恶性特征之间的关系有待进一步研究。
Objective: To investigate the relationship between p53, nm23 and EGF R protein expression and the clinicopathological features of gastric cancer. METHODS: Immunohistochemistry was used to study the expression of p53, nm23, and EGF R proteins in 57 gastric cancers, 20 dysplasias, 20 intestinal metaplasias, and 10 normal gastric mucosas. Results: The three proteins in normal gastric mucosa were negative. The intestinal metaplasia p53 and nm23 were not expressed. The positive rate of EGF R was 5%. The positive rates of p53 in dysplasia and gastric cancer tissues were 15% and 54.4% respectively; the positive rate of nm23 was 5% and 632% respectively; the positive rate of EGF R was 45% and 566% respectively. There was no close relationship between p53 and many clinicopathological features. The expression of nm23 was closely related to the tumor size, growth pattern and prognosis of gastric cancer. The expression of EGF R was negatively correlated with the degree of differentiation and prognosis of gastric cancer and positively correlated with lymph node metastasis. . Conclusions: Simultaneous detection of EGF R, p53, and nm23 is helpful for the early diagnosis of gastric cancer. The expression of EGF R protein in gastric cancer can be used as an index to predict prognosis. Simultaneous detection of nm2 3 can improve its reliability, but nm23 is a predictor. The independent indicators of gastric cancer prognosis and the relationship between p53 protein expression and clinical pathological features of gastric cancer remain to be further studied.