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目的 探讨血管紧张素原 (AGT)基因CD2 35Met→Thr变异与脑梗死的相关性。方法 应用聚合酶链反应 限制性片段长度多态性分析及银染技术 ,分析 12 2例症状性脑梗死病人及 82例正常人AGTM2 3 5T基因多态性。结果 非腔隙性脑梗死病人的T等位基因频率显著高于腔隙脑梗死及正常对照 ,有脑梗死家族史者T等位基因频率高于无脑梗死家族史者但差异无显著性 ,基因多态性在≤ 6 0岁发病和 >6 0岁发病组中差异无显著性。结论 AGTT2 3 5等位基因与非腔隙性脑梗死相关 ,父母亲中有脑血管病患者的病人中T基因型偏高
Objective To investigate the relationship between angiotensinogen (AGT) gene CD235Met → Thr mutation and cerebral infarction. Methods Polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) and silver staining were used to analyze AGTM235T gene polymorphism in 122 patients with symptomatic cerebral infarction and 82 normal controls. Results The frequency of T allele in patients with non-lacunar infarction was significantly higher than those in patients with lacunar infarction and normal controls. The frequency of T allele in patients with family history of cerebral infarction was higher than those without family history of cerebral infarction, but the difference was not significant There was no significant difference in the gene polymorphism between the age of 60 years and the incidence of> 60 years. Conclusion The AGTT235 allele is associated with non-lacunar infarction. The genotype of T is high in patients with cerebrovascular disease in parents