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哺乳期往往会出现骨质和骨代谢的改变。全母乳喂养可加快骨转化并出现短暂的骨丢失,断奶后则可完全恢复。本研究的目的是了解使用Norplant皮下埋植剂(NOR)或孕酮阴道环(PVR)的健康哺乳妇女在母乳喂养期间及断奶后骨转化及骨密度的变化。 选择产后60 d妇女,NOR组29例、PVR组28例、对照组TCu 380A 51例。测量产后第1个月(PM1)、第6个月(PM6)、第12个月(PM12)及断奶后第6或12个月骨密度、血清钙、磷酸酯酶、甲状旁腺素(PTH)、卵泡刺激素(FSH)、雌二醇(E_2)、催乳激素、尿羟脯氨酸、尿肌苷。
Lactation often changes in bone and bone metabolism. Full breastfeeding can accelerate bone turnover and short-term bone loss, after weaning can be completely restored. The purpose of this study was to understand changes in bone turnover and BMD during breastfeeding and after weaning in healthy, lactating women using either Norplant (NOR) or progesterone vaginal ring (PVR). Sixty days after delivery, 29 women were selected as NOR group, 28 as PVR group and 51 as TCu 380A as control group. The bone mineral density, serum calcium, phosphatase and parathyroid hormone (PTH) were measured at the first month postpartum (PM1), the sixth month (PM6), the twelfth month (PM12) and the sixth or twelfth month after weaning ), Follicle stimulating hormone (FSH), estradiol (E2), prolactin, urinary hydroxyproline, urinary inosine.