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目的探讨影响夫精宫腔内人工授精(IUI)临床妊娠率的各种相关因素。方法回顾性分析本生殖中心215例患者进行的488个IUI治疗周期,对女方年龄、不孕年限、不孕病因、IUI周期次数、用药方案、HCG/LH(+)日成熟卵泡数和内膜厚度、授精时机以及注入宫腔内的前向活动精子数(TMS)和妊娠结局的关系进行分析。结果共获得临床妊娠78例,周期妊娠率16.0%,患者妊娠率36.3%。其中患者年龄的增长、子宫内膜厚度>14mm、人授时已排卵者妊娠率显著下降;IUI周期次数的增加≥5周期、TMS<5×106患者的妊娠率也有下降的趋势;男方少弱精子症和子宫内膜异位症患者的妊娠率显著低于宫颈因素和多次促排卵不孕(不明原因?)的患者;患者的不孕年限、用药方案、HCG/LH(+)日成熟的卵泡数对妊娠结局无显著影响,但卵泡个数为3个的妊娠率有增高的趋势。结论女方年龄、子宫内膜厚度、授精时机及不孕因素是影响IUI结局的重要因素,IUI周期次数、成熟卵泡数、注入宫腔的TMS对妊娠结局也有一定的影响。
Objective To investigate the various factors that influence the clinical pregnancy rate of intrauterine insemination (IUI) in Fufang. Methods A retrospective analysis was performed on 488 cycles of IUI treatment in 215 patients with this reproductive center. The age, duration of infertility, causes of infertility, number of cycles of IUI, dosage regimen, number of mature follicles per day, HCG / LH (+) day, Thickness, timing of insemination, and the relationship between the number of forward sperm (TMS) injected into the uterine cavity and the outcome of pregnancy. Results A total of 78 cases of clinical pregnancy were obtained, the pregnancy rate was 16.0% and the pregnancy rate was 36.3%. Among them, the age of patients increased, the thickness of endometrium was> 14mm, the pregnancy rate of human ovulation was significantly decreased; the number of IUI cycles increased more than 5 cycles, the pregnancy rate of TMS <5 × 106 patients also had a tendency to decrease; The pregnancy rate in patients with endometriosis and endometriosis was significantly lower than those in patients with cervical factors and multiple ovulation injections (unexplained?); The duration of infertility, drug regimen, HCG / LH (+) maturation The number of follicles had no significant effect on the pregnancy outcome, but the pregnancy rate of 3 follicles tended to increase. Conclusion The age of female, the thickness of endometrium, timing of insemination and factors of infertility are the important factors affecting the outcome of IUI. The number of IUI cycles, the number of mature follicles, and the TMS injected into the uterine cavity also have some influence on the outcome of pregnancy.