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目的:研究透析、药物等综合治疗甘露醇诱发渗透性肾病的效果。方法:采用血管穿刺或动静脉外瘘进行个体化血液透析/腹膜透析,与药物治疗等综合疗法,对53例(25岁～81岁)甘露醇诱发渗透性肾病患者的治疗效果进行观察及总结。结果:经透析、药物治疗后48名患者病情明显好转,症状逐渐消失,尿量增多、恢复正常,血肌酐(Scr)和尿素氮(BUN)分别由最高1934.8μmol·L-1和49mmol·L-1降至正常。结论:及时恰当透析、药物等综合治疗甘露醇诱发渗透性肾病,能取得满意的疗效。
Objective: To study the effect of dialysis, drugs and other comprehensive treatment of mannitol-induced osmotic nephropathy. Methods: The therapeutic effects of mannitol-induced osmotic nephropathy in 53 patients (25 years old to 81 years old) were observed and summarized by the combination of hemodialysis, peritoneal dialysis and drug therapy with vascular puncture or arteriovenous fistula. . Results: After dialysis and drug treatment, the symptoms of 48 patients improved obviously, symptoms gradually disappeared, urine output increased and returned to normal. Serum creatinine (Scr) and urea nitrogen (BUN) increased from 1934.8μmol·L-1 and 49mmol·L -1 to normal. Conclusion: timely and appropriate dialysis, drugs and other comprehensive treatment of mannitol-induced osmotic nephropathy, can achieve satisfactory results.