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目的检测南京地区3～6岁健康儿童跟骨骨密度(BMD)水平,建立本地区学龄前期儿童超声BMD正常参考值。方法选择2008年4月-2009年6月在南京医科大学附属妇幼保健院体检的579例3～6岁健康儿童,以每0.5岁分组将579例儿童分为≥3.0～3.5岁、≥3.5～4.0岁、≥4.0～4.5岁、≥4.5～5.0岁、≥5.0～5.5岁及≥5.5～6.0岁共6组。采用定量超声仪测定各年龄组儿童足跟部BMD值,同时测量受检者身高、体质量,并计算其体质量指数,应用SPSS10.0软件进行统计学分析。结果各年龄组男童女童之间BMD值比较差异无统计学意义(Pa>0.05),随着年龄增长,BMD在总体上呈增加趋势。3～6岁儿童BMD值与身高呈正相关(r=0.123,P=0.010),与体质量及BMI无相关性(r=0.069、-0.026,P=0.151、0.589)。结论学龄前期儿童BMD无性别差异,BMD与年龄、身高相关,应根据不同年龄组建立儿童BMD参考值。
Objective To detect the bone mineral density (BMD) in healthy children aged 3 ~ 6 years in Nanjing and establish the normal reference value of ultrasound BMD in preschool children in this area. Methods A total of 579 children aged 3 ~ 6 years with physical examination of MCH from Nanjing University of Science and Technology from April 2008 to June 2009 were enrolled in this study. 579 children were divided into three groups of ≥3.0 ~ 3.5 years old, ≥3.5 ~ 4.0 years old, ≥4.0 to 4.5 years old, ≥4.5 to 5.0 years old, ≥5.0 to 5.5 years old and ≥5.5 years to 6.0 years old. Quantitative ultrasound was used to measure the heel BMD of children in all age groups. The height and body mass of the subjects were measured at the same time, and their body mass index was calculated. SPSS 10.0 software was used for statistical analysis. Results There was no significant difference in BMD between boys and girls in all age groups (Pa> 0.05). The BMD increased with age. There was a positive correlation between BMD and height in children aged 3 ~ 6 years (r = 0.123, P = 0.010), but no correlation with body mass and BMI (r = 0.069, -0.026, P = 0.151,0.589). Conclusions There is no gender difference in BMD of pre-school children, BMD is related to age and height, and reference value of children’s BMD should be established according to different age groups.