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目的 :检测尖锐湿疣 (CA)患者人乳头瘤病毒 (HPV)亚型及白介素 2 (IL2 )。方法 :用 PCR检测 61例 CA患者皮损中的 HPV6/11、HPV16/18、HPV-DNA。用双抗体夹心 EL ISA法检测 5 8例 CA患者外周血 IL2。结果 :HPV6/11阳性 40例 ;HPV16/18阳性 12例 ;HPV-DNA阳性、HPV6/11阴性、HPV16/18阴性 9例。HPV16/18阳性组IL 2低于 HPV6/11阳性组 ,两组相比差异有显著性 (P<0 .0 5 )。结论 :HPV16/18感染比 HPV6/11感染有更强的抑制 IL 2产生的作用。推测 CA患者的 HPV16/18感染比 HPV6/11感染更易复发
Objective: To detect human papillomavirus (HPV) subtypes and interleukin 2 (IL2) in patients with condyloma acuminatum (CA). Methods: The HPV6 / 11, HPV16 / 18 and HPV-DNA in 61 CA patients were detected by PCR. Peripheral blood IL2 levels in 58 CA patients were detected by double antibody sandwich ELISA. Results: HPV6 / 11 positive 40 cases; HPV16 / 18 positive 12 cases; HPV-DNA positive, HPV6 / 11 negative, HPV16 / 18 negative in 9 cases. The level of IL-2 in HPV16 / 18 positive group was lower than that in HPV6 / 11 positive group, there was significant difference between the two groups (P <0.05). Conclusion: HPV16 / 18 infection has a stronger effect of inhibiting IL 2 production than HPV6 / 11 infection. It is speculated that CA16 / 18 infection in CA patients is more likely to recur than HPV6 / 11 infection