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对18只大鼠进行内皮素脊髓鞘内注射,观察及记录大鼠后肢功能状态,并将18只大鼠分为3个不同的时间处死,进行病理形态学观察。结果表明:3组均表现缺血缺氧病理改变。2及4h实验组病变重于30min实验组。脊髓下胸段、腰段病变重于颈段及骶尾段。同时发现,大鼠后肢的功能状态与其脊髓相应的病理形态学变化不呈正比。
Eighteen rats were intrathecal injected with endothelin, and the functional status of the hindlimb was observed and recorded. Eighteen rats were sacrificed at three different time points for histopathological observation. The results showed that: all three groups showed pathological changes of hypoxia and hypoxia. 2 and 4h experimental group lesions heavier than 30min experimental group. Spinal lower thoracic, lumbar lesions heavier than the cervical and sacrococcygeal segments. Also found that the functional status of rat hindlimbs and spinal cord corresponding pathological changes are not proportional.