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目的探讨ｐ１６基因蛋白与胆囊癌发生、发展及临床预后的关系。方法采用免疫组化方法对３８例原发性胆囊癌和２０例慢性胆囊炎ｐ１６的表达进行观察。结果ｐ１６在胆囊良性病变中的阳性表达率明显高于胆囊癌（Ｐ＜００１），ｐ１６基因蛋白表达与胆囊癌的浸润性及淋巴结转移密切相关（Ｐ＜００１），但与肿瘤的病理类型及分化程度无相关性（Ｐ＞００５）。结论检测ｐ１６对临床正确估计胆囊癌的浸润性、淋巴结转移潜能及判断预后有重要价值。
Objective To investigate the relationship between p16 gene protein and the occurrence, development and clinical prognosis of gallbladder carcinoma. Methods Immunohistochemical method was used to observe the expression of p16 in 38 cases of primary gallbladder carcinoma and 20 cases of chronic cholecystitis. Results The positive expression rate of p16 in benign gallbladder lesions was significantly higher than that of gallbladder carcinoma (P<001). The expression of p16 gene protein was closely related to invasiveness and lymph node metastasis of gallbladder carcinoma (P<001), but it was associated with tumors. There was no correlation between pathological type and differentiation (P>005). Conclusion The detection of p16 is of great value in the clinical evaluation of gallbladder carcinoma invasiveness, lymph node metastasis potential and prognosis.