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目的观察津力达颗粒联合胰岛素对2型糖尿病(T2DM)患者血糖控制的影响,并探讨其可能的机制。方法将90例单纯使用皮下注射胰岛素(诺和灵30R)而血糖控制不达标的2性糖尿病患者随机分为2组,每组45例。对照组单用胰岛素,治疗组加服津力达颗粒,观察2组治疗前后FPG、2h PG、Hb A1c、FINS、IRI、外源性胰岛素用量的变化等。结果治疗组FPG、2h PG、Hb A1c、FIns、IRI,外源性胰岛素用量均明显下降(p<0.05或<0.01)。结论对于T2DM病患者,津力达颗粒与胰岛素联用可协同降低血糖,提高血糖达标率,减少低血糖症的发生,并有纠正胰岛素抵抗的可能机制。
Objective To observe the effect of Jinlida granule combined with insulin on glycemic control in type 2 diabetes mellitus (T2DM) and to explore its possible mechanism. Methods Totally 90 patients with non-compliance of blood glucose control were randomly divided into two groups (n = 45 in each group) with subcutaneous injection of insulin (Novolin 30R). In the control group, the insulin alone and the treatment group were given Jin Li Da granules. The changes of FPG, 2h PG, Hb A1c, FINS, IRI and exogenous insulin before and after treatment were observed. Results The levels of FPG, 2h PG, Hb A1c, FIns, IRI and exogenous insulin in treatment group were significantly decreased (p <0.05 or <0.01). Conclusions In patients with T2DM, the combination of Jinlida granules and insulin can synergistically decrease blood glucose, improve blood glucose compliance and reduce the incidence of hypoglycemia, and may be a possible mechanism to correct insulin resistance.