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在慢性实验条件下观察到大鼠由学习训练所产生的海马CA_3区习得性长时程突触增强,它的不同发展阶段对新学习任务的习得有不同的作用:(1)在它的形成阶段及巩固阶段对新学习均有易化作用,虽然两个阶段突触效应增强的程度都处于相同的高水平,但后者的易化作用相对要大些,提示这两个发展阶段突触的可塑性变化是有差异的;还有,新学习任务的训练并没有引起突触效应的进一步增强,表明突触效应的长时程增强有“饱和”现象。(2)在它消退后,对新学习任务的习得没有影响。上述结果提示学习的组织形式不同,可从突触机制上影响学习的效果,并进一步证明习得性长时程突触增强是学习和记忆的神经基础。
Under chronic experimental conditions, learning long-term hippocampal CA_3 synaptic enhancement induced by learning and training in rats has been observed. Its different stages of development have different effects on the acquisition of new learning tasks: (1) Although the synaptic effects in both stages were enhanced to the same high level, the ease of the latter was relatively larger, suggesting that the two stages of development Synaptic plasticity changes are different; Also, the training of new learning tasks did not cause further enhancement of synaptic effects, suggesting that the synaptic effect of long-term potentiation “saturation” phenomenon. (2) has no effect on the acquisition of new learning tasks after it recedes. The above results suggest that different organizational forms of learning affect the learning effect from synaptic mechanisms and further prove that learning long-term synaptic enhancement is the neural basis for learning and memory.