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目的探讨甲醛致胎鼠肝微核率与染色体畸变。方法随机将妊娠小鼠(孕13天)分为5组:腹腔注射甲醛(0.00、0.20、2.00、20.00mg/kg)染毒组、环磷酰胺(30mg/kg)阳性对照组,实验至妊娠第14天即染毒后18小时脱颈椎处死孕鼠,剥离两侧子宫,每侧各取一胎鼠,断头放出外周血,取胎肝,采用胎肝微核试验和胎肝染色体畸变试验,检测胎肝血微核率和染色体畸变率。结果2.00、20.00mg/kg甲醛染毒组胎肝微核率及胎肝染色体畸变率与阴性对照组比较差异有显著性(P<0.01);染色体畸变主要表现为染色体断裂、多倍体等畸形。结论甲醛可致胎鼠肝微核率与染色体畸变。
Objective To investigate the micronuclei frequency and chromosomal aberrations of fetal rat liver induced by formaldehyde. Methods Pregnant mice (13 days pregnant) were randomly divided into 5 groups: intraperitoneal injection of formaldehyde (0.00,0.20,2.00,20.00mg / kg) and cyclophosphamide (30mg / kg) On the 14th day, the pregnant rats were removed by cervical debridement 18 hours after the exposure and the fetuses were removed on both sides of the uterus. One fetus was taken from each side, and the peripheral blood was decapitated. Fetal liver micronucleus test and fetal liver chromosome aberration test , Detection of fetal liver micronucleus rate and chromosome aberration rate. Results The micronucleus rate of fetal liver and chromosome aberration rate of fetal liver were significantly different between the two groups (P <0.01) at 2.00 and 20.00 mg / kg formaldehyde exposure. Chromosome aberrations were mainly caused by chromosome rupture and polyploidy . Conclusion Formaldehyde can cause fetal liver micronucleus rate and chromosome aberration.