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目的:研究酸枣仁油对行为绝望小鼠抑郁模型的影响。方法:选取健康雄性昆明种小鼠,随机分为5组,空白对照组、阳性药组、酸枣仁油50,100,200 mg.kg-1剂量组。连续ig 7 d,每天1次,通过小鼠自主活动实验、小鼠强迫游泳实验和小鼠悬尾实验,观察酸枣仁油对小鼠抑郁作用的影响。结果:酸枣仁油不同剂量组均能减少小鼠强迫游泳和悬尾不动时间,与空白组比较具有显著差异(P<0.05,P<0.01)。结论:酸枣仁油具有一定的抗小鼠实验性抑郁作用。
Objective: To study the effects of jujube kernel oil on the depression model in behavioral desperation mice. Methods: Healthy male Kunming mice were randomly divided into 5 groups, blank control group, positive control group, Suanzaoren oil 50,100,200 mg.kg-1 dose group. On the seventh consecutive day, once a day, mice were subjected to spontaneous activity test, mice forced swimming test and mice tail suspension test to observe the effect of jujube kernel oil on depression in mice. Results: All the different doses of wild jujube seed oil could reduce forced swimming and hang-up time of mice, which was significantly different from that of the blank group (P <0.05, P <0.01). Conclusion: Suanzaoren oil has a certain anti-mouse experimental depression.