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Objective:To report 4 cases of biphenotypic acute leukemia(BAL)with t(8;21)(q22;q22),and analyze the characteristics of morphology,immune phenotype,chromosome karyotype(MIC)and clinical manifestations.Methods:The BAL patients with t(8;21)(q22;q22)(group A)were compared with the randomly selected BAL patients with other clonical chromo- somal changes(group B)and acute myeloid leukemia M2 cases with t(8;21)(q22;q22)(group C)in MIC and clinical features. Results:BAL with t(8;21)(q22;q22)showed acute myeloid leukemia with high percentages of blast cells morphologically; revealed co-positive to B-lymphoid and myeloid lineages,frequent and high expressions of CD34 and CD33;were responsive to chemotherapy for myeloid and lymphocytic leukemia simultaneously well.Conclusion:A new subset of BAL with t(8;21)(q22;q22)was reported,and this suggests that the leukemia colony with t(8;21)(q22;q22)might originate from early phase of hematopoiesis.
Objective: To report 4 cases of biphenotypic acute leukemia (BAL) with t (8; 21) (q22; q22), and analyze the characteristics of morphology, immune phenotype, chromosome karyotype (MIC) and clinical manifestations. Methods: The BAL patients (group A) were compared with the randomly selected BAL patients with other clonical chromo- somal changes (group B) and acute myeloid leukemia M2 cases with t (8; 21) (q22 ; q22) (group C) in MIC and clinical features. Results: BAL with t (8; 21) (q22; q22) showed acute myeloid leukemia with high percentages of blast cells morphologically; revealed co-positive to B-lymphoid and myeloid lineages, frequent and high expressions of CD34 and CD33; were responsive to chemotherapy for myeloid and lymphocytic leukemia simultaneously well. Confluence: A new subset of BAL with t (8; 21) (q22; q22) was reported, and this suggests that the leukemia colony with t (8; 21) (q22; q22) might originate from early phase of hematopoiesis.