他汀类(statins)药物是最近20年治疗高胆固醇血症的新药,因为该药疗效显著,不良反应小,耐受性好,受到临床应用的重视和好评。近年来发现以辛伐他汀(simvastatin)为主的他汀类药物可促进成骨细胞增殖,骨形成增加,但其确切的机制尚不清楚。医学界开始高度关注该药在骨改建方面的 Statins drugs are the new drugs to treat hypercholesterolemia in the recent 20 years because of their significant curative effect, small adverse reactions and good tolerability. They are valued and praised by clinical applications. In recent years, it has been found that simvastatin-based statins can promote osteoblast proliferation and bone formation, but the exact mechanism is still unclear. The medical community has begun to pay great attention to the drug in bone remodeling