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目的通过调查徐州高碘及碘适宜地区妊娠早期妇女甲状腺功能减退症的发生率,初步建立不同碘地区妊娠早期甲减流行病学的数据库,为甲状腺疾病的防治提供依据.方法在高碘和碘适宜地区分别随机选取120例进行孕检的孕早期妇女,予以甲状腺功能检查,同时留取随机中段尿,利用砷铈催化法进行尿碘定量检测.结果在适碘地区,甲减、亚临床甲减、低 T4血症的检出率分别为2.2%、7.8%、2.2%,而在高碘地区,检出率分别为3.6%、32.6%、4.0%.其中高碘地区亚临床甲减的发生率明显高于碘适宜地区.结论徐州高碘地区孕妇的亚临床甲减患病率明显高于适碘地区,可能与碘摄入过量有关.因此有必要在高碘地区检测妊娠早期尿碘及甲状腺功能.“,”Objective To study the prevalence of hypothyroidism in early pregnant women living in both excess and sufficient water iodine area in XuZhou, and to establish an epidemiological database of hypothyroidism among early pregnant women in different water iodine area in XuZhou in order to guide our clinical practise.Methods Early pregnant women were randomly selected 120 cases of pregnant examination in the high iodine and iodine area,to test their thyroid function and urinary iodine. Result In sufficient water iodine area, the prevalence of hypothyroidism, subclinical hypothyroidism, hypothyroxinaemia were2.2%、7.8%、2.2%, and in excess water iodine area,the data is3.6%、32.6%、4.0%. The prevalence of subclinical hypothyroidism was significantly higher in excess water iodine region than that in sufficient water iodine area.Conclusion The prevalence of subclinical hypothyroidism was significantly higher in excess water iodine region than that in sufficient water iodine area in XuZhou,and may be related to high iodine intake.Therefore,it’s necessary to test the thyroid function and urinary iodine during early pregnant women in excess water iodine aera.