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目的:采用系统评价-Meta分析的方法,评价雪诺同阴道缓释凝胶对比安琪坦阴道给药作为体外受精-胚胎移植(IVF/ICSI-ET)黄体支持的疗效。方法:检索截至2016年2月前国内外比较雪诺同阴道缓释凝胶对比安琪坦胶囊阴道给药进行IVF/ICSIET黄体支持疗效的RCTs进行系统评价。研究对象为采用IVF/ICSI方式进行助孕、新鲜周期移植的患者;年龄小于40周岁等。具体评价指标包括:临床妊娠率、早期流产率等辅助生殖常规评价指标。结果:(1)Meta分析共纳入6篇随机对照研究,纳入的6篇文献在基本资料方面均无显著性差异;(2)Meta分析显示:阴道用雪诺同进行黄体支持相对于安琪坦,在提高临床妊娠率、胚胎着床率方面具有显著优势(P<0.05),而并不影响早期流产率、异位妊娠率等其他结局指标。结论:综合既往随机对照试验的二次研究分析显示,在IVF/ICSI周期使用雪诺同行黄体支持临床疗效高于安琪坦;但雪诺同临床使用费用相对较高,患者在具体选择用药时应根据自身情况个体化用药;同时本研究纳入文献数量相对较少,未来需行大样本研究进一步验证。
OBJECTIVE: To evaluate the efficacy of amphoteric vaginal delivery of Angelovan as a corpus luteum in vitro fertilization-embryo transfer (IVF / ICSI-ET) compared with vaginal sustained-release gel using a systematic review-Meta analysis. METHODS: The systematic reviews of RCTs performed with IVF / ICSIET corpus luteum support by vaginal administration of Angel Capsule compared with that of compared with vaginal sustained release gel of Snow Snow until Feb. 2016 were searched at home and abroad. The subjects of study were IVF / ICSI patients with assisted pregnancy and fresh-cycle transplantation; those younger than 40 years of age and so on. Specific evaluation indicators include: clinical pregnancy rate, early miscarriage rate and other assisted reproductive routine evaluation index. Results: (1) A total of 6 randomized controlled trials were included in the Meta-analysis. Six articles included in the meta-analysis showed no significant difference in basic data. (2) Meta-analysis showed that vaginal support of Snow Conservancy (P <0.05) in improving clinical pregnancy rate and embryo implantation rate without affecting other outcomes such as early miscarriage rate and ectopic pregnancy rate. CONCLUSIONS: The results of the second round of randomized controlled trials in the previous study showed that the clinical efficacy of syringa luteolol in the IVF / ICSI cycle was higher than that of Angel; however, the costs associated with clinical use were relatively high. Patients under specific choice of medication Should be based on their own individualized medication; the same time the number of included in this study is relatively small, the need for future large sample further validation.