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目的探讨川崎病并发冠状动脉病变的危险因素。方法对60例确诊为川崎病患儿的临床表现,超声心动图、急性期C-反应蛋白、胆固醇、血沉、血小板、血红蛋白、白细胞等资料进行计量资料t检验、计数资料χ2检验、Logistic多元回归分析。结果60例川崎病并发冠状动脉病变18例(30%)。单因素分析显示:发热天数、血小板、C-反应蛋白、胆固醇与冠状动脉病变发生率有密切关系(P<0.01)。多因素Logistic多元回归分析显示:C-反应蛋白、胆固醇与冠状动脉病变密切相关(P<0.01)。结论对川崎病进行综合分析,可对该病作出及时的预后判断,予早期干预治疗,促进冠状动脉病变的恢复。
Objective To explore the risk factors of Kawasaki disease complicated with coronary artery disease. Methods The clinical data, echocardiography, acute phase C-reactive protein, cholesterol, erythrocyte sedimentation rate, platelet, hemoglobin and white blood cells in 60 children diagnosed as Kawasaki disease were measured by t test, count data χ2 test, Logistic multiple regression analysis. Results 60 cases of Kawasaki disease complicated by coronary artery lesions in 18 cases (30%). Univariate analysis showed that the days of fever, platelets, C-reactive protein and cholesterol were closely related to the incidence of coronary artery disease (P <0.01). Multivariate Logistic multiple regression analysis showed that C-reactive protein and cholesterol were closely related to coronary artery disease (P <0.01). Conclusion A comprehensive analysis of Kawasaki disease can make a timely prognosis of the disease to early intervention and promote the recovery of coronary lesions.