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目的分析自体CIK细胞回输治疗对晚期肺癌患者免疫功能及生活质量的影响,为临床治疗方式的选择提供支持。方法按研究需要对近两年内我院治疗的晚期肺癌患者进行筛选,选取的76例为研究对象。将其随机分为观察和对照组。分别予以单纯化疗治疗和化疗联合自体CIK细胞回输治疗。并组间比较及分析外周血CD4+、CD8+和CD4+/CD8+等T淋巴细胞亚群,KPS评分及生活质量等数据。结果观察组治疗后CD4+、CD8+和CD4+/CD8+等数据均具有显著优势(P<0.05);观察组治疗后KPS评分具有显著优势(P<0.05);观察组治疗后3个月的生活质量评分显著高于对照组(P<0.05)。结论自体CIK细胞回输治疗用于晚期肺癌的辅助治疗能够提升患者的免疫功能和生活质量,对改善患者的生存时间和生活质量均具有重要意义。
Objective To analyze the influence of autologous CIK cell reinfusion therapy on immune function and quality of life in patients with advanced lung cancer and provide support for the choice of clinical treatment modalities. Methods According to the research needs of patients with advanced lung cancer treated in our hospital in the past two years, 76 patients were selected as the research object. They were randomly divided into observation and control groups. Respectively to chemotherapy and chemotherapy combined with autologous CIK cell infusion therapy. The data of T lymphocyte subsets such as CD4 +, CD8 + and CD4 + / CD8 +, KPS score and quality of life in peripheral blood were compared and analyzed. Results The data of CD4 +, CD8 + and CD4 + / CD8 + in the observation group after treatment showed significant advantages (P <0.05); the KPS score of the observation group was significantly superior to that of the control group (P <0.05); the quality of life score Significantly higher than the control group (P <0.05). CONCLUSIONS: The self-administered CIK cells for adjuvant therapy for advanced lung cancer can improve the immune function and quality of life in patients with advanced lung cancer. It is of great significance to improve the survival time and quality of life of patients.