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目的：探讨胺碘酮治疗心律失常的最小有效维持量。方法：心律失常７８例（用其他抗心律失常药治疗无效者）改用胺碘酮０．２ｇ，ｐｏ，ｔｉｄ治疗，其中６０例自觉症状消失，心律失常控制获显效，对取得显效的６０例（男性３６例，女性２４例；年龄６２±ｓ７ａ）病人采用逐渐减量的方法，由胺碘酮０．２ｇ，ｐｏ，ｂｉｄ，逐渐减至０．１ｇ，０．０５或０．０２５ｇ，ｐｏ，ｑｄ。结果：经过２４±１５ｍｏ的减量观察，发现胺碘酮治疗心律失常的最小有效维持量为０．０５～０．１ｇ，ｐｏ，ｑｄ，与体重无关。当药量减至０．０６６ｇ／ｄ时其毒副作用基本消失。结论：胺碘酮０．０５～０．１ｇ，ｐｏ，ｑｄ是安全、有效、可长期服用。房室传导阻滞及心动过缓病人忌用。
Objective: To investigate the minimum effective maintenance dose of amiodarone for arrhythmia. Methods: 78 cases of arrhythmia (with other anti-arrhythmic drugs ineffective treatment) to use amiodarone 0.2g, po, tid treatment, of which 60 cases of symptoms disappeared, arrhythmia control was markedly effective in obtaining effective in 60 cases (36 males, 24 females; age 62 ± s7a) were tapered by amiodarone 0.2g, po, bid, gradually reduced to 0.1g, 0.05 or 0.025g, po , Qd. Results: After 24 ± 15mo decrement observation, found that the minimum effective maintenance dose of amiodarone arrhythmia 0.05 ~ 0.1g, po, qd, and has nothing to do with body weight. When the dose reduced to 0.066g / d its side effects disappeared. Conclusion: Amiodarone 0.05 ~ 0.1g, po, qd is safe, effective, long-term use. Atrioventricular block and bradycardia patients hanged.