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胆色素类结石在我国比胆固醇类结石常见,治疗也更困难。它的主要成分是胆红素。应用胆汁沉淀试验研究胆红素等胆石组分由胆汁中沉淀出来的过程表明,胆汁中胆酸盐含量的增高,对这一过程可能有抑制作用,而胆红素含量的增高则可能有利于沉淀过程的进行。槙哲夫等认为:胆汁中的β-葡萄糖醛酸苷酶(β-glucuronidase,简写为β-G),能促使直接胆红素水解为间接胆红素进而形成结石。而葡萄糖醛酸、葡萄糖二酸则对β-G活性有抑制作用。因此,我们在体外向胆汁中加入胆盐、葡萄糖醛酸和葡萄糖二酸,以进一步探讨其对胆红素沉淀生成的影响。
Bile pigment stones in our country than cholesterol stones common treatment is more difficult. Its main ingredient is bilirubin. The application of bile precipitation test to study the process of gallstone components such as bilirubin precipitated from bile showed that the increase of cholate in bile may have an inhibitory effect on this process and the increase of bilirubin content may be beneficial Precipitation process.槙 Tetsuo et al .: Bile in the β-glucuronidase (β-glucuronidase, abbreviated as β-G), can promote direct bilirubin hydrolysis of indirect bilirubin and the formation of stones. Glucuronic acid and glucaric acid, however, inhibit β-G activity. Therefore, we added bile salts, glucuronic acid and glucaric acid to bile in vitro to further investigate its effect on bilirubin deposition.