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目的:了解淫鹑方对上呼吸道感染的治疗效果并探讨其药理作用机制。方法:临床收集了20例反复呼吸道感染患者作为检测、治疗对象,检测其T淋巴细胞亚型及血液流变学,应用淫鹑方治疗4周后,再次检测其T淋巴细胞亚型及血液流变学。比较治疗前后二者的变化。结果:反复呼吸道感染患者的CD3+、CD4+淋巴细胞明显低于正常人群(P<0.01或P<0.05);CD8+淋巴细胞则明显高于正常人群(P<0.05);用药后反复呼吸道感染患者的CD3+、CD4+淋巴细胞百分比与用药前相比较明显上升,有显著的统计学意义(P<0.01或P<0.05)。治疗后全血高切流阻,全血中切流阻,全血低切流阻,血浆黏度,聚集指数等各项指标明显低于用药前,有显著统计学意义(P<0.01或P<0.05)。结论:淫鹑方对上呼吸道感染患者有确切的治疗效果,能改善患者的免疫功能和血液流变学。
Objective: To understand the curative effect of obstructing quail on upper respiratory tract infection and to explore its pharmacological mechanism. Methods: Twenty patients with recurrent respiratory tract infection were collected and tested as T lymphocyte subtypes and hemorheology in clinic. After 4 weeks of treatment with Gui-quang decoction, the T lymphocyte subsets and blood flow were tested again Change learning. Compare the changes before and after treatment. Results: CD3 + and CD4 + lymphocytes in patients with recurrent respiratory tract infection were significantly lower than those in normal controls (P <0.01 or P <0.05), while CD8 + lymphocytes were significantly higher in patients with recurrent respiratory tract infections than those in normal controls (P <0.05) (P <0.01 or P <0.05). The percentages of CD4 + lymphocytes were significantly higher than those before treatment (P <0.01 or P <0.05). After treatment, the indexes of whole blood high shear flow resistance, whole blood shear flow resistance, whole blood low shear flow resistance, plasma viscosity and aggregation index were significantly lower than those before treatment (P <0.01 or P < 0.05). Conclusion: Obsidian prescription for patients with upper respiratory tract infection has the exact therapeutic effect, can improve the patient’s immune function and hemorheology.