Loranthus micranthus is the species of mistletoe peculiar to the eastern province of Nigeria.It has been shown to possess anti-diabetic,anumotility,antimicrobial and antihypertensive activities which are host-tree dependent. The antimicrobial activity was found to vary with the season during which the plant was harvested.We are of the opinion that this species should possess immunomodulating potentials as have been reported for the European species,Viscum album.In our efforts to establish the bio-activities and active principles in our local mistletoe, the immunomodulatory activity of n-hexane and methanol extracts from Loranthus micranthus parasitic on Persea americana was assessed at three dose levels ranging from 100 to 400 mg/kg body weight using delayed type hypersensitivity reaction(DTHR) and cyclophosphamide-induced myelosuppression models in mice.This was compared with responses from a standard immunostimulatory drug,levamisole.Preliminary phytochemical analysis of the plant showed the presence of tannins,flavonoids,alkaloids,terpenoids,carbohydrates and saponins.Regression analysis indicated a dose-dependent response relationship in the parameters measured with over 170%increase for both extracts at the highest dose level.The one way ANOVA test showed significant variation in the parameters between the controls and the different dose levels.However,at 95%confidence level,(P<0.05),there was no statistically significant difference between the two extracts, an indication that the active immunomodulant(s) could be both in the polar and non-polar crude extract.In conclusion,the present results have established some immune stimulating actions of the Eastern Nigeria mistletoe, Loranthus micranthus thus indicating that this variant of the semi parasitic plant holds a strong promise as an immunostimulatory candidate.There is therefore,a basis for further detailed investigation on the fractions and specific constituents.Thus,these extracts from Loranthus micranthus possess pronounced immune stimulating action comparable to Levamisole in mouse-based models.