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关于锑剂的药理学和毒理学,过去曾有几篇综述。本文摘要报导最近四年来的主要文献,作为以上综述的补充和继续。除五价锑特别注明外,文内一般指三价锑。锑的吸收、分布和排泄小腸高位吸收锑较多,小腸低位和结腸吸收较少。想到改变腸道酸碱度可以控制酒石酸锑钾的电离度和沉淀量,用大白鼠和豚鼠作实验,証明先用酸液灌流腸道,然后灌流酒石酸锑钾,則锑的吸收较多;但酒石酸氢钾并无促进吸收的作用。BAL-葡糖甙能
Regarding the pharmacology and toxicology of antimony agents, there have been several reviews in the past. This summary of the article covers the main literature from the last four years as a supplement and continuation of the above review. Except for the pentavalent antimony, the text generally refers to the trivalent antimony. Antimony absorption, distribution and excretion of intestinal absorption of antimony more, low intestinal and colon less absorbed. Thinking of changing the pH of the gut can control the degree of ionization and precipitation of antimony potassium tartrate. Experiments with rats and guinea pigs showed that the intestinal tract was first perfused with acid, and then antimony potassium tartrate was infused, whereas antimony was absorbed more. However, Potassium does not promote absorption. BAL-glucoside can