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目的:考察曲克芦丁在0.9%氯化钠(非聚氯乙烯软袋,非PVC软袋)、0.9%氯化钠(玻璃瓶)、5%葡萄糖(非PVC软袋)、5%葡萄糖(玻璃瓶)4组输液环境中的稳定性。方法:以高效液相色谱外标法定时测量曲克芦丁含量,并观察外观,测量pH变化。结果:24h内,在0.9%氯化钠(非PVC软袋)、0.9%氯化钠(玻璃瓶)、5%葡萄糖(非PVC软袋)、5%葡萄糖(玻璃瓶)4组之间,曲克芦丁含量数据各组间差异无显著性(P>0.05);各组内液体的含量、外观、pH无明显变化。结论:曲克芦丁在0.9%氯化钠(非PVC软袋)、0.9%氯化钠(玻璃瓶)、5%葡萄糖(非PVC软袋)、5%葡萄糖(玻璃瓶)4种环境中配伍稳定性良好,且可短时间放置(24h内)使用。
OBJECTIVE: To investigate the effect of troxerutin in 0.9% sodium chloride (non-polyvinyl chloride soft bag, non-PVC soft bag), 0.9% sodium chloride (glass bottle), 5% dextrose (Glass bottles) 4 infusion stability of the environment. Methods: The content of troxerutin was measured by external standard method of high performance liquid chromatography (HPLC) and the appearance was observed. The change of pH was measured. Results: Within 24 hours, four groups were incubated in 0.9% sodium chloride (non-PVC soft bag), 0.9% sodium chloride (glass bottle), 5% dextrose (non-PVC soft bag) and 5% dextrose (glass bottle) The content of troxerutin in each group had no significant difference (P> 0.05). There was no significant change in the content, appearance and pH of liquid in each group. CONCLUSION: Troxerutin is effective in four environments of 0.9% sodium chloride (non-PVC pouch), 0.9% sodium chloride (glass bottle), 5% dextrose (non-PVC pouch) and 5% dextrose Compatibility stability is good, and can be placed in a short time (24h) use.