Mannich反应是在有机合成中广泛采用的反应,是甲醛与胺及含有活性氢的分子(如甲基酮等)发生缩合反应,是制备β-胺基酮类的方便方法.但一般认为芳香胺不能参加这个反应,因此,可先制成脂肪胺的Mannich碱,然后用芳香胺交换来制备β-芳胺基酮. 我们曾利用琥珀酰亚胺-N-Mannich碱,与芳香酮的交换反应来制备β-芳胺基 The Mannich reaction is a widely used reaction in organic synthesis and is a convenient method for the preparation of β-aminoketones by the condensation of formaldehyde with molecules of amines and active hydrogen such as methyl ketones, etc. It is generally believed that aromatic amines Can not participate in this reaction, therefore, Mannich base of aliphatic amine can be made first, and then the aromatic amine exchange can be used to prepare β-arylamino ketone.We have used succinimide-N-Mannich base, exchange reaction with aromatic ketone Β-arylamino group