色素上皮衍生因子(pigment epithelium-derived factor,PEDF)是一种多效的神经营养因子和新生血管抑制因子,其在视网膜的生长发育及许多疾病病理过程中起着神经分化、神经营养、神经保护和抑制新生血管形成等作用,并可抗肿瘤和调控一些炎症反应。本文主要是综述目前对PEDF的生物学特点、作用及其在视网膜疾病中的应用研究状况,并推测其可能作用机制,展望其在视网膜疾病的临床治疗中的应用前景。 Pigment epithelium-derived factor (PEDF) is a pleiotropic neurotrophic factor and angiogenesis inhibitor that plays a role in neural development, neurotrophic and neuroprotection in retinal growth and development and in many pathological processes And inhibit angiogenesis and other effects, and anti-tumor and regulate some inflammatory response. This article mainly summarizes the current biological characteristics of PEDF, its role in retinal diseases and research status, and speculated that its possible mechanism of action, and its prospects in the clinical treatment of retinal diseases.