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本文通过直接肝内注射及静脉滴注促肝细胞生长素（ＰＨＧＦ）两种方法治疗慢性乙型肝炎患者２６例，比较两者对肝炎组织活动性指数（ＨＡＩ）及肝纤维化指数（ＨＦＩ）的影响。结果治疗后，直接肝内注射组的ＨＡＩ及ＨＦＩ均显著低于治疗前（Ｐ＜０．００１），并显著低于静脉给药组的ＨＡＩ及ＨＦＩ（Ｐ＜０．００１）；静脉给药组的ＨＡＩ显著低于治疗前（Ｐ＜０．０５），ＨＦＩ与治疗前无显著性差异（Ｐ＞０．０５）。结论：直接肝内注射ＰＨＧＦ在短期内即可显著改善慢性乙肝肝组织的炎症反应及纤维化程度，且经两次以上肝活组织检查随访，其病理改变与治疗后未见明显恶化
In this paper, 26 cases of chronic hepatitis B patients were treated by direct intrahepatic injection and intravenous injection of hepatocyte growth-promoting factor (PHGF). The two groups were compared on the indexes of activity index (HAI) and hepatic fibrosis index (HFI) Impact. Results After treatment, HAI and HFI in the direct intrahepatic injection group were significantly lower than those before treatment (P <0.001), and were significantly lower than those in the intravenous HAI and HFI groups (P <0.001) HAI was significantly lower than that before treatment (P <0.05), but there was no significant difference between HFI and before treatment (P> 0.05). CONCLUSION: Direct intrahepatic injection of PHGF can significantly improve the inflammatory response and fibrosis in chronic hepatitis B liver tissue in a short term. After two or more cycles of liver biopsy, the pathological changes and treatment showed no obvious deterioration