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目的：探讨胃粘膜肠化生细胞ＤＮＡ含量与增殖状态分型、硫酸化粘液分泌状况之间的关系。方法：采用ＤＮＡ图像分析技术测定３９４例胃粘膜活检及外科手术标本中细胞ＤＮＡ含量，并对１８７例伴肠化生慢性萎缩性胃炎作免疫组化与粘液组化套染，进行肠化生增殖状态分型。结论：胃粘膜出现肠化生和异型增生、癌变时，出现异倍体细胞且百分率显著增高（Ｐ＜０．０１）；高增殖型肠化生中异倍体细胞的百分率显著高于中、低增殖型肠化生（Ｐ＜０．０１）。结论：提示高增殖型肠化生与胃癌的发生密切相关。
OBJECTIVE: To investigate the relationship between DNA content and proliferation status and the status of sulfated mucus secretion in intestinal metaplasia of gastric mucosa. METHODS: DNA image analysis was used to determine DNA content in 394 gastric biopsy specimens and surgical specimens. 187 cases of chronic atrophic gastritis with intestinal metaplasia were used for immunohistochemistry and mucous histochemistry for intestinal metaplasia. State classification. Conclusions: In the presence of intestinal metaplasia, dysplasia and carcinogenesis in gastric mucosa, aneuploid cells appeared and the percentage increased significantly (P<0.01); the percentage of aneuploid cells in high-proliferation intestinal metaplasia was significantly higher than that in the middle, Low proliferative intestinal metaplasia (P < 0.01). Conclusion: It suggests that high-proliferation intestinal metaplasia is closely related to the occurrence of gastric cancer.