口服皮质类固醇引发医源性Cushing综合征已有广泛报道,同样,局部使用类固醇制剂由于其高效及长时间使用而被全身吸收也会产生这一不良反应。然而,对吸入或鼻内使用皮质类固醇导致症状明显的Cushing综合征还认识不足。作者报道了2例儿童长时间鼻内使用倍他米松后发生Cushing综合征。 Oral corticosteroids cause iatrogenic Cushing syndrome has been widely reported, the same, topical steroid formulations due to its high efficiency and long-term use and systemic absorption will produce this adverse reaction. However, Cushing’s syndrome, which causes obvious symptoms for inhaled or intranasal corticosteroids, is also poorly understood. The authors report that Cushing’s syndrome developed in 2 children after prolonged intranasal administration of betamethasone.