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目的:探讨日间腹腔镜胆囊切除术的镇痛方式。方法:将300例拟行手术的患者随机分为6组，每组使用不同的镇痛方案。记录术后第2、4、8和12小时的VAS评分、术后血压、CRP、IL-6以及术后不良反应的发生。结果:日间腹腔镜胆囊切除术成功率为66.22%。随着术后时间的延长，各组患者的动态VAS评分逐渐降低，其中B组和C组在术后第2小时和第4小时低于A组（n P<0.05）。D、E和F组在术后各时间点与A组差异有统计学意义（n P<0.05）。术后第8小时和12小时B组比D组和C组比E组差异有统计学意义（n P<0.05）。B组和C组与F组相比在术后第12小时差异有统计学意义（n P<0.05）。术后组间CRP和IL-6比较差异有统计学意义（n P<0.05）。使用镇痛泵的患者术后头晕、恶心和延迟出院人数显著增多（n P<0.05）。n 结论:罗哌卡因局部浸润联合术后帕瑞昔布钠静脉滴注是一种较好的日间腹腔镜胆囊切除术后的镇痛方案。“,”Objective:To explore the analgesic methods in ambulatory laparoscopic cholecystectomy (LC) patients.Methods:Three hundred patients were randomly divided into six groups receiving different analgesic regimen. VAS scores, postoperative blood pressure, CRP, IL-6, and the occurrence of postoperative adverse effects were recorded at 2, 4, 8, and 12 h postoperatively.Results:The success rate of ambulatory LC in this study was 66.22%. The dynamic VAS scores of patients in each group gradually decreased with time elapsing, with groups B and C being significantly lower than group A at 2 h and 4 h postoperatively (n P<0.05). Groups D, E and F were significantly different from group A at all postoperative time points (n P<0.05). There was a statistically significant difference at 8 h and 12 h postoperatively in group Bn vs. group D and group C n vs. group E (all n P<0.05). There was significant difference at the 12 h postoperatively between groups (B and C) compared to group F (n P<0.05). There was a significant difference in CRP and IL-6 between the groups (alln P<0.05). Postoperative dizziness, nausea and delayed discharge were significantly higher in patients using analgesic pumps (n P<0.05).n Conclusion:Local infiltration of ropivacaine combined with postoperative parecoxib sodium drip is a recommended analgesic regimen.