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目的探讨复方醋酸环丙孕酮与二甲双胍治疗多囊卵巢综合征(PCOS)并胰岛素抵抗(IR)的临床效果。方法选取符合诊断标准的PCOS患者96例,依据给药方案分为两组,单药组48例给予复方醋酸环丙孕酮周期性治疗,联合组48例在复方醋酸环丙孕酮治疗基础上加用二甲双胍连续治疗。比较两组治疗前后性激素水平、糖脂代谢指标及预后指标。结果治疗后联合组性激素水平及糖脂代谢指标均优于单药组,差异均有统计学意义(P<0.05)。联合组患者排卵率(90.15%)、妊娠率(54.42%)均高于对照组排卵率(80.54%)、妊娠率(40.31%),差异有统计学意义(P<0.05)。结论复方醋酸环丙孕酮与二甲双胍联合治疗PCOS并IR,可有效改善患者临床症状、生殖内分泌水平及代谢紊乱。
Objective To investigate the clinical effects of compound cyproterone acetate and metformin in the treatment of polycystic ovary syndrome (PCOS) and insulin resistance (IR). Methods Ninety-six patients with PCOS who met the diagnostic criteria were divided into two groups according to the dosage regimen. 48 patients in the single drug group were treated cyclophosphamide acetate periodically, and 48 patients in the combined group were treated with compound cyproterone acetate Plus metformin continuous treatment. The levels of sex hormones, glucose and lipid metabolism and prognosis were compared between the two groups before and after treatment. Results After treatment, the levels of sex hormones and glucose and lipid metabolism in the combination group were better than those in the single drug group (all P <0.05). The ovulation rate (90.15%) and pregnancy rate (54.42%) in the combined group were significantly higher than those in the control group (80.54%) and pregnancy rate (40.31%), with significant difference (P <0.05). Conclusion Combination of cyproterone acetate and metformin in the treatment of PCOS and IR can effectively improve the clinical symptoms, reproductive endocrine levels and metabolic disorders.