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采用ＡＢＣ免疫组化技术，对２４例食管鳞癌组织中的溶菌酶阳性巨噬细胞（Ｌｙｓｏｚｙｍｅｐｏｓｉｔｉｖｅｍａｃｒｏｐｈａｇｅ，ＬＰＭ）和Ｓ－１００蛋白阳性Ｌａｎｇｅｒｈａｎｓ细胞（ＬＣ）进行了原位观察和定量研究。结果显示：在食管粘膜和各级鳞癌组织中均可见到ＩＰＭ及ＬＣ浸润。从食管正常粘膜、异型增生粘膜到癌组织，ＬＰＭ数量逐渐增多（Ｐ＜０．０１或０．０５）。癌组织内ＬＰＭＭ数量与肿瘤的分化程度、大体类型关系密切，提示食管癌组织内浸润的巨噬细胞与食管癌的发生发展有一定的联系。另外，ＬＰＭ与ＬＣ分布明显不同，数量无相关性，说明两者在抗肿瘤免疫中具有不同的功能。
Using ABC immunohistochemical technique, in situ observation and quantitative study of lysozyme-positive macrophages (LPM) and S-100 protein positive Langerhans cells (LC) in 24 esophageal squamous cell carcinoma tissues were performed. The results showed that IPM and LC infiltration can be seen in esophageal mucosa and all grades of squamous cell carcinoma. From the normal esophageal mucosa and dysplastic mucosa to cancerous tissue, the number of LPM gradually increased (P<0.01 or 0.05). The number of LPMM in cancer tissues is closely related to the degree of differentiation and gross type of tumors, suggesting that infiltration of macrophages in esophageal cancer tissue has a certain relationship with the occurrence and development of esophageal cancer. In addition, the distribution of LPM and LC was significantly different and the number was not correlated, indicating that both have different functions in anti-tumor immunity.