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目的 :评价动脉灌注大剂量亚叶酸钙和 5 -氟尿嘧啶对晚期胃癌的效果。方法 :对 30例晚期胃癌病人 ,采用介入方法对肿瘤供血动脉进行大剂量亚叶酸钙和 5 -氟尿嘧啶等化疗药物灌注 ,观察肿瘤体积变化及随访生存期 ,并与静脉给药化疗病人对照。结果 :实验组 CR(完全缓解 ) +PR(部分缓解 ) 5 6 .7%、 MR(微效 ) +SD(好转 ) 30 % ,对照组 CR +PR 16 .7%、MR +SD 30 % ;实验组 12、18和 2 4个月的生存率分别为 90 %、76 .7%和 5 0 % ,对照组分别为 6 6 .7%、6 0 %和 10 %。结论 :采用介入方法灌注大剂量亚叶酸钙和 5 -氟尿嘧啶为主的化疗药可使肿瘤缩小、明显提高晚期胃癌病人的生存率。
PURPOSE: To evaluate the effect of intraarterial infusion of large doses of leucovorin and 5 - fluorouracil on advanced gastric cancer. Methods: Thirty patients with advanced gastric cancer were treated with high dose leucovorin and 5 - fluorouracil chemotherapeutic drugs via the interventional method. The changes of tumor volume and follow - up survival were observed and compared with those of intravenous chemotherapy. Results: CR (complete remission) + PR (partial remission) was 56.7%, MR 30%, SD + CR 16.7%, MR + SD 30% in the control group. The survival rates at 12, 18 and 24 months in experimental group were 90%, 76.7% and 50% respectively, while those in control group were respectively 6.6%, 60% and 10%. Conclusion: The chemotherapeutic drugs with high dose of leucovorin and 5 - fluorouracil infusion can reduce the tumor size and significantly improve the survival rate of patients with advanced gastric cancer.