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曾报告在集体预防的免疫人群中很快发生对乙胺嘧啶和二氯胍的抗性。本研究的目的是比较两药的情况并试图阐明这种抗性的机理。研究对象是在利比里亚北部的3个疟疾流行村的2～9岁儿童。第1个村庄每周给乙胺嘧啶2mg/kg,第2个村庄给二氯胍1.5mg/kg,第3个村庄作为不给药的对照。给药时目睹儿童吞入药片,如果一年中儿童离开当地超过一次者不列入研究对象。实验开始时与2年结束时,按Hackett氏法测定脾脏大小,作疟原虫涂片检查与红细胞压积水平测定。
Resistance to pyrimethamine and dichloroguanidine has recently been reported in immunized populations for collective prophylaxis. The purpose of this study was to compare the two drugs and try to elucidate the mechanism of this resistance. The study population was 2 to 9 years old in 3 malaria-endemic villages in northern Liberia. The first village gave pyrimethamine 2 mg / kg weekly, the second village 1.5 mg / kg of dichloroguanidine, and the third village the non-administration control. At the time of administration, children were seen swallowing tablets, which were not included in the study if the child left the area more than once a year. At the beginning of the experiment and at the end of 2 years, the size of the spleen was determined by Hackett ’s method and the Plasmodium smear and hematocrit levels were determined.