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目的 :观察静脉用合贝爽 (地尔硫 )治疗不稳定型心绞痛的临床疗效和安全性。方法 :随机选择同期收治的 5 0例不稳定型心绞痛患者 ,分为地尔硫 组 19例和硝酸酯治疗组 31例。地尔硫 组 :以合贝爽注射剂 10mg溶于 4 0ml生理盐水中 ,10分钟内静脉注射 ,继以 4 0mg合贝爽注射剂加入 5 %葡萄糖注射液 2 5 0ml中以 10mg/h速度静滴 ,维持 2天。硝酸酯组 :以 (4 0～ 6 0 )mg鲁南欣康注射液加入 5 %葡萄糖注射液 2 5 0ml中以 (7～ 10 )mg/h的速度静滴 ,持续 2天。结果 :在症状和心电图改善方面 ,地尔硫 组疗效均显著优于硝酸酯组 (P <0 .0 5 )。结论 :地尔硫 治疗不稳定型心绞痛的临床疗效显著优于单硝酸异山梨醇 ,且安全可靠。
OBJECTIVE: To observe the clinical efficacy and safety of intravenous Shuangbo (diltiazem) in the treatment of unstable angina pectoris. Methods: A total of 50 patients with unstable angina pectoris admitted in the same period were randomly divided into diltiazem group (n = 19) and nitric acid ester group (n = 31). Diltiazem group: co-Pui cool injection 10mg dissolved in 40ml normal saline, intravenous injection within 10 minutes, followed by 40mg Beibei injection added 5% glucose injection 250ml intravenous infusion at a rate of 10mg / h , For 2 days. Nitrate group: intravenous infusion of (40 ~ 60) mg Lunanxinkang injection into 250ml of 5% glucose injection at (7 ~ 10) mg / h for 2 days. Results: The efficacy of diltiazem group was significantly better than that of nitrate group in improving symptoms and ECG (P <0.05). Conclusion: The clinical efficacy of diltiazem in the treatment of unstable angina pectoris is significantly better than that of isosorbide mononitrate and is safe and reliable.