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哮喘是由多种炎性细胞参与的气道慢性炎症,其特征是气道高反应性、炎细胞浸润及细胞因子的增加。一氧化氮(NO)具有舒张肺血管和支气管平滑肌的作用。内皮素-1(ET-1)是已知最强的内源性血管活性肽。他们参与许多呼吸系统疾病的发病过程。我们通过测定哮喘患者发作期和缓解期NO和ET-1含量,探讨NO和ET-1相互间的关系和临床意义。1 对象与方法1.1 对象 根据1997年第二届全国哮喘学术会议制订的诊断标准,选取1997年12月至1998年11月我院门诊和住院明确诊断为支气管哮喘患者31例。其中男16例,女15例,年龄16～64岁。健康对照组30名,男8名,女22名,年龄18～58岁,组间年龄差别无显著性(P>0.05)。
Asthma is a chronic inflammation of the airways that is involved in a variety of inflammatory cells and is characterized by airway hyperresponsiveness, inflammatory cell infiltration, and an increase in cytokines. Nitric oxide (NO) relaxes pulmonary and bronchial smooth muscles. Endothelin-1 (ET-1) is the most potent endogenous vasoactive peptide. They are involved in the pathogenesis of many respiratory diseases. We determine the relationship between NO and ET-1 and their clinical significance by measuring the levels of NO and ET-1 in the episodes and remissions of asthmatic patients. 1 Subjects and Methods 1.1 Subjects According to the 1997 National Conference on the development of the second national asthma diagnostic criteria selected from December 1997 to November 1998 in our hospital outpatient and hospitalized diagnosed as bronchial asthma in 31 patients. Including 16 males and 15 females, aged 16 to 64 years. There were 30 healthy controls, 8 males and 22 females, aged from 18 to 58 years old. There was no significant difference in age between groups (P> 0.05).