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有机磷杀虫剂(OP)在世界范围内广泛用于防治植物病、虫害,它对人和动物的主要毒性来自抑制乙酰胆碱酯酶引起的神经毒性,同时还具有免疫毒性,影响免疫应答,抑制抗体产生和T细胞增殖,增加自身抗体,抑制自然杀伤(NK)细胞、细胞毒性T淋巴(CTL)细胞的活性。国内对有机磷杀虫剂免疫毒性机制的研究,尤其是对其抑制NK细胞溶细胞活性的机制研究还很少。现就国外关于OP的免疫毒性及其机制的研究进展作一综述。
Organophosphorus pesticides (OPs) are widely used in the world to control plant diseases and insect pests. Their main toxicity to humans and animals comes from inhibition of the neurotoxicity induced by acetylcholinesterase, as well as immunotoxicity, immune response, Antibody production and T cell proliferation, increase autoantibodies, and inhibit the activity of natural killer (NK) cells and cytotoxic T lymphocytes (CTLs). Domestic research on the mechanism of immunotoxicity of organophosphorus insecticides, especially its mechanism of inhibiting the cytolytic activity of NK cells are still few. Now on the foreign on the immunotoxicity of OP and its mechanism of research progress are reviewed.