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目的探讨重度子痫前期患者尿蛋白严重程度对孕周及新生儿体重的影响。方法回顾性分析150例重度子痫前期患者的临床资料,统计两组尿蛋白严重程度对孕周及新生儿体重的影响。结果 150例患者资料统计分析结果显示重度蛋白尿组入院时<34孕周患者比例高于轻度组、入院及终止妊娠时孕周较轻度组小、期待治疗时间较轻度组长、24 h尿蛋白高于轻度组,差异均有统计学意义(P<0.05)。孕28~32周活产的新生儿出生体重在轻、重度蛋白尿两组之间差异无统计学意义(P>0.05);在其余孕周,重度蛋白尿组新生儿出生体重<轻度蛋白尿组,差异有统计学意义(P<0.05)。结论尿蛋白的严重程度可作为预测子痫前期患者病情进展的重要指标之一,用于指导临床实践。
Objective To investigate the effect of urinary protein severity on gestational age and newborn weight in patients with severe preeclampsia. Methods The clinical data of 150 patients with severe preeclampsia were retrospectively analyzed. The effects of urinary protein severity on the gestational age and the weight of neonates were analyzed. Results The data analysis of 150 patients showed that the proportion of patients with severe proteinuria during admission <34 gestational weeks was significantly higher than that of mild patients. The gestational age at hospitalization and termination of pregnancy was smaller, and the expectant treatment time was lighter. h urine protein higher than mild group, the difference was statistically significant (P <0.05). The birth weight of neonates born between 28 and 32 weeks of gestation was not significantly different between the two groups (P> 0.05). In the other gestational weeks, the birth weight of neonates with severe proteinuria was lower than that of mild protein Urine group, the difference was statistically significant (P <0.05). Conclusions The severity of urinary protein may be used as one of the important indexes to predict the progression of the disease in preeclampsia and to guide the clinical practice.