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取代苯基甲酰基脲类微生物,被蚊虫幼虫取食后,能抑制虫体内几丁质合成酶,从而使虫体几丁质合成受到严重障碍,不能正常的形成新表皮,幼虫蜕皮变态受阻而死亡。由于该类化合物杀虫效果好,有一定残效,对人畜安全,不污染环境,因此受到国内外广泛重视。为了寻找适合我国条件,效果较好的该类杀虫剂,我们与有关单位协作共筛选三十一种化合物,并以TH—6040和TH—6038为对比药物,测定其对淡色库蚊幼虫的毒力。结果TH—6040及TH6038的LD_(50)分别为0.0042ppm,0.0105ppm,筛选的化合物除4个样品对蚊幼无效外,其余27个样品均有不同程度效果,其中毒力超过TH—6040者一个,超过TH—6038者5个,说明该类化合物作为新型杀虫剂具有很大潜力,目前该项工作正在深入研究中。
Substituted phenylformylurea microorganisms, after being eaten by mosquito larvae, can inhibit chitin synthase in parasites so that the chitin synthesis of parasites is severely impaired and the new epidermis can not be formed normally, and larva molting metamorphosis is blocked death. Due to their insecticidal effect and certain residual effects, these compounds are safe to humans and animals and do not pollute the environment, and are therefore widely regarded at home and abroad. Thirty-one compounds were screened in collaboration with relevant institutes in order to find suitable pesticides suitable for our conditions. TH-6040 and TH-6038 were used as the comparative drugs to determine their effects on larvae of Culex pipiens pallens Toxicity. Results LD_ (50) of TH-6040 and TH6038 were 0.0042ppm and 0.0105ppm, respectively. Except 4 samples of mosquitoes, 4 of the selected compounds were ineffective against mosquito, while the other 27 samples all had different degrees of toxicity. One, more than TH-6038 were 5, indicating that these compounds have great potential as a new insecticide, the work is currently under study.