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目的：探讨白细胞介素－５（ＩＬ－５）在支气管哮喘发病机制中的作用。方法：随机选择８例哮喘患者雾化吸入人重组ＩＬ－５，并分别于吸入前、吸入后２，２４和４８ｈ进行外周血有核细胞计数和分类，并以放射免疫法测定血清中嗜酸阳离子蛋白（ＥＣＰ）及总ＩｇＥ水平。结果：吸入ＩＬ－５后嗜酸性粒细胞（ＥＯＳ）占细胞总数的百分比、ＥＯＳ绝对细胞数以及ＥＣＰ水平均随时间而明显升高，至２４ｈ达最高值，４８ｈ后仍维持在较高水平；而ＩＬ－５在整个实验过程中对血清总ＩｇＥ水平并无明显影响。结论：吸入重组ＩＬ－５不仅可以促使循环中ＥＯＳ数明显增多，而且还能导致其活化从而参与哮喘的发病过程。
Objective: To investigate the role of interleukin-5 (IL-5) in the pathogenesis of bronchial asthma. Methods: Eight patients with asthma were randomly selected to inhaled recombinant human interleukin-5 (IL-5). Peripheral blood mononuclear cells were counted and classified at 2, 24 and 48 hours after inhalation. The levels of eosinophils Cationic protein (ECP) and total IgE levels. Results: The percentage of eosinophils (EOS) in total cells, the absolute number of EOS and the level of ECP significantly increased with time after inhaling IL-5, up to the highest value at 24 hours and remained at a relatively high level after 48 hours. However, IL-5 had no significant effect on serum total IgE levels throughout the experiment. Conclusion: Inhaled recombinant IL-5 can not only promote the number of circulating EOS significantly increased, but also lead to its activation and thus participate in the pathogenesis of asthma.