肺癌患者的一线化疗总的缓解率不是很高,很多患者在化疗中或化疗后出现疾病进展,需进一步治疗。最近,对晚期NSCLC的二线化疗的临床研究显示,二线化疗不但可以提高患者的生存期,而且可以改善肿瘤相关症状和提高生活质量,且使患者对止痛药及姑息性放疗的需求减少。本文对最近晚期NSCLC的二线化疗的研究进行简要的总结。 The overall response rate of first-line chemotherapy in patients with lung cancer is not very high, many patients in chemotherapy or chemotherapy after the disease progression, the need for further treatment. Recently, clinical studies of second-line chemotherapy for advanced NSCLC have shown that second-line chemotherapy not only increases patient survival but also improves cancer-related symptoms and quality of life, and reduces the need for painkillers and palliative radiotherapy. This article summarizes the recent advances in second-line chemotherapy for advanced non-small cell lung cancer (NSCLC).