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目的:观察前列地尔治疗高血压肾病致慢性肾功能不全的临床效果。方法:选择2012年6月-2015年11月期间在我院接受治疗的高血压肾病所致慢性肾功能不全患者94例作为研究对象,随机划入观察组和对照组,分别使用前列地尔和丹参酮ⅡA磺酸钠注射液治疗,比较两组患者的肌酐、尿素、24h尿蛋白、24h尿量四项生化指标检测结果。结果:观察组患者肌酐、尿素、24h尿蛋白、24h尿量四项生化指标检测结果均优于对照组,组间差异有统计学意义,P<0.05。结论:前列地尔治疗高血压肾病致慢性肾功能不全临床效果显著,能够显著延缓病情发展,减轻对肾脏损伤,维持水、电解质和酸碱平衡,值得临床应用和推广。
Objective: To observe the clinical effect of alprostadil in the treatment of chronic renal insufficiency caused by hypertensive nephropathy. Methods: A total of 94 patients with chronic renal failure caused by hypertensive nephropathy treated in our hospital from June 2012 to November 2015 were selected as study subjects and randomly assigned to observation group and control group, Tanshinone Ⅱ A sodium sulfonate injection treatment, two groups of patients were compared creatinine, urea, 24h urine protein, 24h urine output of four biochemical test results. Results: The results of biochemical detection of creatinine, urea, 24h urinary protein and 24h urine in observation group were better than those in control group. The difference between the two groups was statistically significant (P <0.05). Conclusion: Alprostadil is effective in treating chronic renal insufficiency due to hypertensive nephropathy. It can significantly delay the progression of the disease, reduce the damage to the kidney and maintain the balance of water, electrolytes and acid-base. It is worthy of clinical application and promotion.