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多囊卵巢综合征(polycystic ovary syndrome,PCOS)是与女性生殖和代谢相关的常见内分泌障碍性疾病,各种内分泌激素通过与子宫内膜受体或和受体结合发挥作用,具体包括甾体类激素,胰岛素和瘦素等。各种激素,激素受体,甚至细胞内信号传递分子种类及表达量的改变,使PCOS患者子宫内膜可能表现为分泌期反应不良、单纯性增生、复杂性增生、不典型性增生甚至癌变等。此外,其子宫内膜受体及增殖凋亡因子表达量的改变影响子宫内膜的功能和胚胎的植入,这也是PCOS患者高流产率低妊娠率的原因之一。PCOS对子宫内膜的影响尤其是对分子水平作用机制的研究是国外近年研究的热点之一。
Polycystic ovary syndrome (PCOS) is a common endocrine disorders associated with female reproductive and metabolic processes. A variety of endocrine hormones play a role by binding to endometrial receptors and receptors, including steroids Hormones, insulin and leptin and so on. Various hormones, hormone receptors, and even intracellular signaling molecules in the type and amount of change, so that endometrial PCOS patients may show poor response during secretory phase, simple hyperplasia, complex hyperplasia, atypical hyperplasia or even cancerous . In addition, changes in the expression of endometrial receptors and proliferative apoptotic factors affect endometrial function and embryo implantation, which is one of the reasons for the low pregnancy rate in patients with PCOS. The effect of PCOS on the endometrium, especially the molecular mechanism of action, is one of the hot spots in recent years.