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应用琼脂糖电泳法观察了21例AMI患者血浆CK-MM亚型演变。发病2～3小时,CKMM_3%和MM_3/MM_1比值即已显著上升,分别为30.6±4.8%和0.90±0.34,并于10.8±2.3小时同时达高峰(比CK-MB早12小时),峰值分别为57.9±6.4%和4.94±2.31,而后CK-MM_3迅速下降;CK-MM_1变化与其相反;发病15～24小时的主要亚型为CK-MM_2。提示观察亚型演变确实有助于AMI的早期诊断和梗塞时间与再灌注的判断。
The changes of plasma CK-MM subtypes in 21 AMI patients were observed by agarose gel electrophoresis. The ratio of CKMM_3% to MM_3 / MM_1 had a significant increase from 2 to 3 hours after onset of disease (30.6 ± 4.8% and 0.90 ± 0.34, respectively) and peaked at 10.8 ± 2.3 hours (12 hours earlier than CK-MB) Which was 57.9 ± 6.4% and 4.94 ± 2.31, respectively. Then the CK-MM_3 decreased rapidly. The change of CK-MM_1 was opposite. The main subtype of CK-MM_2 was 15-24 hours. Prompt observation of subtype evolution does contribute to the early diagnosis of AMI and infarction time and reperfusion judgment.