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目的调查和分析2013年-2015年舟山地区妇女的人乳头状瘤病毒(HPV)E6/E7 mRNA阳性率变迁。方法选取2013年1月-2015年12月在本院就诊的本地常住妇女503例,采集宫颈脱落细胞,荧光定量PCR法检测HPV E6/E7 mRNA表达,以HPV E6/E7 mRNA>103为阳性。结果共计HPV E6/E7 mRNA阳性88例,总阳性率为17.49%。≤30岁组中,2015年的HPV E6/E7 mRNA阳性率高于2014年,差异有统计学意义(χ~2=4.08,P<0.05),≥41岁组中,2015年的HPV E6/E7 mRNA阳性率高于2014年,差异有统计学意义(χ~2=8.92,P<0.01)。2015年的乡村组HPV E6/E7 mRNA阳性率高于2014年,差异有统计学意义(χ~2=11.14,P<0.01)。结论舟山地区≥41岁和乡村妇女是HPV E6/E7 mRNA阳性高发人群,有必要对其加强宫颈癌病变监控。
Objective To investigate and analyze the positive rate of HPV E6 / E7 mRNA in women in Zhoushan from 2013 to 2015. Methods 503 cases of local resident women were selected from January 2013 to December 2015 in our hospital. The exfoliated cells of cervix were collected. The expression of HPV E6 / E7 mRNA was detected by fluorescence quantitative PCR with HPV E6 / E7 mRNA> 103 as positive. Results Total HPV E6 / E7 mRNA positive 88 cases, the total positive rate was 17.49%. The positive rate of HPV E6 / E7 mRNA in 2015 was significantly higher than that in 2014 (χ ~ 2 = 4.08, P <0.05) in the age group of ≤30 years. In the group of ≥41 years, the HPV E6 / The positive rate of E7 mRNA was higher than that of 2014, with a significant difference (χ ~ 2 = 8.92, P <0.01). In 2015, the positive rate of HPV E6 / E7 mRNA in rural group was higher than that in 2014, with a significant difference (χ ~ 2 = 11.14, P <0.01). Conclusion The prevalence of HPV E6 / E7 mRNA in rural women ≥41 years old and in rural areas in Zhoushan is very high. It is necessary to monitor the cervical lesions.